• Costs and benefits of natural transformation in Acinetobacter baylyi 

      Hülter, Nils Fredrik; Sørum, Vidar; Borch-Pedersen, Kristina; Liljegren, Mikkel Meyn; Utnes, Ane; Primicerio, Raul; Harms, Klaus; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-15)
      Background <br> Natural transformation enables acquisition of adaptive traits and drives genome evolution in prokaryotes. Yet, the selective forces responsible for the evolution and maintenance of natural transformation remain elusive since taken-up DNA has also been hypothesized to provide benefits such as nutrients or templates for DNA repair to individual cells. <br> Results <br> We investigated ...
    • No effect of natural transformation on the evolution of resistance to bacteriophages in the Acinetobacter baylyi model system. 

      Mcleman, Amy; Sierocinski, Pawel; Hesse, E; Buckling, A; Perron, G; Hülter, Nils Fredrik; Johnsen, Pål Jarle; Vos, M (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      The adaptive benefits of natural transformation, the active uptake of free DNA molecules from the environment followed by incorporation of this DNA into the genome, may be the improved response to selection resulting from increased genetic variation. Drawing analogies with sexual reproduction, transformation may be particularly beneficial when selection rapidly fluctuates during coevolution with ...
    • Persistence of a pKPN3-like CTX-M-15-encoding IncFIIK plasmid in a Klebsiella pneumonia ST17 host during two years of intestinal colonization 

      Löhr, Iren Høyland; Hülter, Nils Fredrik; Bernhoff, Eva; Johnsen, Pål Jarle; Sundsfjord, Arnfinn; Naseer, Mohammed Umaer (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-04)
      Objectives To characterize the CTX-M-15-encoding plasmid in a Klebsiella pneumoniae ST17 strain, responsible for an outbreak at a Norwegian neonatal intensive care unit and subsequent colonization of affected children for up to two years. To identify plasmid-mediated features relevant for the outbreak dynamics, and to investigate the plasmids capability of horizontal transfer, its segregational ...